Summary: Researchers discovered a mechanism linking high sugar consumption to an increased risk of Alzheimer’s disease. The study found elevated blood glucose and increased sugar intake can lead to the proliferation of amyloid plaques in the brain – a characteristic sign of Alzheimer’s.
The study also revealed the role of neuronal ATP-sensitive potassium channels, or KATP channels, in this process. Manipulation of these channels could offer a potential new therapeutic avenue for Alzheimer’s.
- Elevated blood sugar and higher sugar intake are found to promote the buildup of amyloid plaques in the brain, increasing the risk of Alzheimer’s.
- The research team identified ATP-sensitive potassium channels (KATP channels) on neurons that link metabolic changes to amyloid-beta production in the brain.
- Potential therapeutic benefits could arise from the pharmacological manipulation of these KATP channels in diabetic and pre-diabetic patients.